Functional Differentiation of Multiple Dopamine D1-Like Receptors by NNC 01-0012
نویسندگان
چکیده
منابع مشابه
Inhibitory effects of dopamine on spinal synaptic transmission via dopamine D1-like receptors in neonatal rats.
BACKGROUND AND PURPOSE Dopamine released from the endings of descending dopaminergic nerve fibres in the spinal cord may be involved in modulating functions such as locomotion and nociception. Here, we examined the effects of dopamine on spinal synaptic transmissions in rats. EXPERIMENTAL APPROACH Spinal reflex potentials, monosynaptic reflex potential (MSR) and slow ventral root potential (s...
متن کاملModulation of Neuronal Differentiation by Dopamine Receptors
90 | 2010 | VOLUME 1 VANDERBILT REVIEWS | NEUROSCIENCE ©2010 Vanderbilt Brain Institute. All rights reserved. Brain development is a prolonged and dynamic process that begins in the prenatal period and continues through adolescence . This phenomenon can be appreciated by looking at the examples of spatiotemporal dynamics of dendritic differentiation and synaptogenesis. Therefore these dynamics ...
متن کاملVoltage-dependent neuromodulation of Na+ channels by D1-like dopamine receptors in rat hippocampal neurons.
Activation of D1-like dopamine (DA) receptors reduces peak Na+ current in acutely isolated hippocampal neurons through phosphorylation of the alpha subunit of the Na+ channel by cAMP-dependent protein kinase (PKA). Here we report that neuromodulation of Na+ currents by DA receptors via PKA is voltage-dependent in the range of -110 to -70 mV and is also sensitive to concurrent activation of prot...
متن کاملDopamine depresses excitatory synaptic transmission onto rat subicular neurons via presynaptic D1-like dopamine receptors.
Schizophrenia is considered to be associated with an abnormal functioning of the hippocampal output. The high clinical potency of antipsychotics that act as antagonists at dopamine (DA) receptors indicate a hyperfunction of the dopaminergic system. The subiculum obtains information from area CA1 and the entorhinal cortex and represents the major output region of the hippocampal complex. To clar...
متن کاملDopamine suppresses persistent network activity via D1-like dopamine receptors in rat medial entorhinal cortex
Cortical networks display persistent activity in the form of periods of sustained synchronous depolarizations ('UP states') punctuated by periods of relative hyperpolarization ('DOWN states'), which together form the slow oscillation. UP states are known to be synaptically generated and are sustained by a dynamic balance of excitation and inhibition, with fast ionotropic glutamatergic excitator...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2002
ISSN: 0022-3042,1471-4159
DOI: 10.1046/j.1471-4159.1998.71041685.x